Scientists report that obesity can break down the protective blood-brain blockade resulting in difficulties with memory and learning. They recognized that the constant foundation of the receptor Adora2a on to the endothelial cells that stock this significant barrier in the brain can allow factors from the blood to enter the brain and influence the function of neurons. The MCG (Medical College of Georgia) researchers have shown that when they slab Adora2a in a replica of diet-induced obesity, this significant barrier function is uphold. Dr. Alexis M. Stranahan—Neuroscientist at the MCG—said, “We are aware that insulin resistance and obesity break down the blood-brain barrier in animal models and humans, but exactly how is still a mystery.” The study was published in the Journal of Neuroscience.
Apparently, adenosine is a neurotransmitter in the brain that aids in sleep and regulate the blood pressure; in the body, it is also a constituent of the cell energy ATP (adenosine triphosphate). Adenosine also triggers receptors Adora1a and Adora2a on the endothelial cells, which usually maintains healthy relationships amid blood flow and brain activity. The problems occur with chronic activation, mostly in the brain, which is what turns out with obesity, reports Stranahan. Individuals having obesity and diabetes have high rates of cognitive injury as they age and most of the associated structural changes are in the hippocampus region.
Recently, the MCG was in news as its study stated that gene levels can aid in predicting prognosis for colorectal cancer. The levels of a gene that aids the immune system to distinguish the good cells from the bad can be a good pointer of prognosis in individuals having colorectal cancers, researchers from MCG report. Looking at 15 genes well-known to be linked with colorectal cancers—8 linked with lower survival rates and 7 with higher—the scientists discovered that CCR4 gene was present in higher levels in individuals with a good prognosis, even in those identified with late-stage disease.