Investigators at MIT, the Ragon Institute of MGH, and Harvard have employed a new method to verify particular amino acids in the HIV’ protein structure that seem essential to the virus’ ability to replicate and function. They also have discovered that the immune systems of people naturally capable of controlling HIV infection aim at these amino acids using CD8 pathogen-killing T cells. This is a capability witnessed even in controllers who do not transport editions of the HLA-B protein earlier related with HIV control. The report is posted in the Science journal and can guide the progress of largely protective vaccines to suppress and prevent HIV infection.
“Our results offer a putative method for a primary element of victorious immune management of HIV and assist separate HIV control from particular editions of HLA genes, which makes our results generally appropriate to the worldwide population,” claimed Gaurav Gaiha, from the Gastrointestinal Unit of Massachusetts General Hospital (MGH) and the Ragon Institute, to the media in an interview.
On a related note, new researches from Western University and Lawson Health Research Institute have discovered that HIV can be transmitted for the first time via the sharing of tools employed to make drugs before injection and that an easy interference—heating the tool for 10 seconds with a cigarette lighter—can kill the HIV virus, avoiding that transmission. The results, employed to tell a public health campaign dubbed as “Cook Your Wash,” have assisted lower HIV transmission rates in Ontario.
The two researches posted in JAIDS (Journal of Acquired Immune Deficiency Syndrome) were started in 2016 to deal with a public health emergency in Ontario when HIV rates among injection drug consumers increased more than 2 times. Between August 2016 and June 2017, the research group studied 119 injection drug consumers to know their risk for HIV and injection behaviors.