Analyzing the entire group of genes and all the proteins formed by colon cancer tissues from the patient samples has disclosed that a more complete view of the tumor that directs at new cancer biological systems and possible new treatment strategies. This multi-institutional and multidisciplinary research was conducted by researchers at BCM (Baylor College of Medicine). The study was published in the journal Cell. The study strongly supports the complete characterization of tumor tissues as a way to direct further research leading to untimely new treatments and diagnostic strategies.
Dr. Bing Zhang—Professor at the BCM—said, “This is the first research that studied all the genes and proteins in tissue samples from a group of individuals having colon cancer, comparing normal and tumor-adjacent tissues.” The research team also included researchers from the Department of Energy’s PNNL (Pacific Northwest National Laboratory), Washington University, Vanderbilt University, and the NCI (National Cancer Institute). The team generated the proteomic and genomic data and utilized bioinformatics examines the data. The outcome is the first methodical catalog of the diverse proteins formed by adjacent normal tissues and colon cancer tumors. The researchers learned that proteomic and genomic data balance each other in ways that present scientists with a better knowledge of what goes inside colon cancer cells.
On a similar note, recently a study showed that the discovery of colon cancer pathway can show the way to new targeted treatments. The UMass’s (University of Massachusetts) food science scientists have pinpointed a group of enzymes engaged in tumor progression that can be aimed to treat or prevent colon cancer. Guodong Zhang—Assistant Professor of Food Science—said, “We feel this is a very motivating discovery. Our research found a new therapeutic target and can help in developing innovative strategies to decrease the risks of colon cancer.” The study was issued in the journal Cancer Research.